PMPA
Data Sheet
For research use only. Not for human use.
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| CAS No. | 173039-10-6 | Cat. No. | BCP08861 |
| Name | PMPA | ||
| Synonyms | NAALADaseinhibitor；2-PMPA；2-(Phosphonomethyl)pentanedioic acid; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C6H11O7P | M. Wt | 226.12 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PMPA is a NAALADase inhibitor. PMPA increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice. Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. PMPA attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia.Highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a Ki value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO). | ||
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