Y 39983 dihydrochloride New
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CAS No. | 173897-44-4 | Cat. No. | BCP18325 |
Name | Y 39983 dihydrochloride | ||
Synonyms | Y-39983 2HCl;Y-39983 dihydrochloride;Y39983 dihydrochloride;Y-33075; Y 33075; Y33075; | ||
SMILES | C(C1=CC=C(C=C1)C(=O)NC2=C3C=CNC3=NC=C2)N.Cl.Cl | ||
Chemical Name | |||
Formula | C16H18Cl2N4O | M. Wt | 353.25 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Y-33075 dihydrochloride is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.Y-39983, also known as Y-33075, is a potent and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK. Y-39983 attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Y-39983 downregulates RhoA/Rho-associated kinase expression during its promotion of axonal regeneration. Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. |
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