TAS-103 dihydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 174634-09-4 | Cat. No. | BCP10009 |
| Related Products | 174634-08-3（TAS-103） | ||
| Name | TAS-103 dihydrochloride | ||
| Synonyms | BMS-247615;BMS 247615;BMS247615;TAS 103;TAS103; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C20H21Cl2N3O2 | M. Wt | 406.31 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be a potent topoisomerase II poison. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05). The combination with CDDP augmented the antitumor activity of TAS-103 (p<0.05), indicating that CDDP is one of the most potent candidates to be used in combination with TAS-103 . TAS-103 may be useful in the chemotherapy of colorectal cancer. | ||
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