PF-06747775
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1776112-90-3 | Cat. No. | BCP17532 |
| Name | PF-06747775 | ||
| Synonyms | PF06747775;PF 06747775;CPI402257;CPI 402257;CPI-402257; Mavelertinib; | ||
| SMILES | CN1C=C(C(=N1)OC)NC2=C3C(=NC(=N2)N4CC(C(C4)F)NC(=O)C=C)N(C=N3)C | ||
| Chemical Name | |||
| Formula | C18H22FN9O2 | M. Wt | 415.42 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-06747775, also known as mavelertinib, is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. EGFR T790M inhibitor PF-06747775 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. Compared to some other EGFR inhibitors, PF-06747775 may have therapeutic benefits in tumors with T790M-mediated drug resistance. | ||
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