GSK-J4 Hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1797983-09-5 | Cat. No. | BCP20167 |
| Name | GSK-J4 Hydrochloride | ||
| Synonyms | GSK-J4 HCl; GSK J4 HCl;GSKJ4 Hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H28ClN5O2 | M. Wt | 453.96 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK-J4 is a cell permeable, potent and selective histone demethylase. GSK-J4 is a prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family. GSK-J4 is used to probe the consequences of demethylation of H3K27me3. GSK-J4 inhibits the lipopolysaccharide-induced production of cytokines, including pro-inflammatory tumour necrosis factor (TNF). | ||
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