GGTI298
Data Sheet
For research use only. Not for human use.
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| CAS No. | 180977-44-0 | Cat. No. | BCP24854 |
| Name | GGTI298 | ||
| Synonyms | GGTI 298; GGTI-298; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C27H33N3O3S | M. Wt | 479.63 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GGTI-298 is a potent geranylgeranyltransferase-I (GGTase-I) inhibitor with potential antitumor actrivity. GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells. GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity. GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner. GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells. | ||
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