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Sulfatinib Chemical Structure

Sulfatinib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP19610CAS No. ：1816307-67-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1816307-67-1 Cat. No. BCP19610
Name Sulfatinib
Synonyms HMPL012;HMPL-012; HMPL 012; surufatinib;
SMILES
Chemical Name
Formula C24H28N6O3S M. Wt 480.59
Purity 98% Storage Store at 4-8°C
Description Sulfatinib, also known as surufatinib, is an orally bioavailable, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, and the fibroblast growth factor receptor type 1 (FGFR1), with potential antineoplastic and anti-angiogenic activities. Upon oral administration, sulfatinib binds to and inhibits VEGFRs and FGFR1 thereby inhibiting VEGFR- and FGFR1-mediated signal transduction pathways. This leads to a reduction of angiogenesis and tumor cell proliferation in VEGFR/FGFR1-overexpressing tumor cells. Expression of VEGFRs and FGFR1 may be upregulated in a variety of tumor cell types.
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H-NMR HPLC
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