VX 853-2 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP19954CAS No. ：183313-30-6Purity：98%

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CAS No.	183313-30-6	Cat. No.	BCP19954
Name	VX 853-2
Synonyms	VX 853-2;VX853-2;Timcodar dimesilate;
SMILES	CN(C(CC1=CC=C(C=C1)Cl)C(=O)N(CC2=CC=CC=C2)C(CCC3=CC=NC=C3)CCC4=CC=NC=C4)C(=O)C(=O)C5=CC(=C(C(=C5)OC)OC)OC.CS(=O)(=O)O.CS(=O)(=O)O
Chemical Name
Formula	C45H53ClN4O12S2	M. Wt	941.5
Purity	98%	Storage	Store at 4-8°C
Description	Timcodar, also known as VX-853, is a Novel Multidrug Resistance Inhibitor. Timcodar was under clinical trials to treat cancaners and other diseases. Timcodar potentiated the activity of ethidium bromide (EtBr), a model efflux substrate, against three clinically significant gram-positive pathogens: Staphylococcus aureus, Enterococcus faecalis, and Streptococcus pneumoniae. Similar to reserpine, VX-853 directly blocked EtBr efflux in S. aureus. Furthermore, VX-853 was effective in lowering the MICs of several clinically used antibiotics, including fluoroquinolones, suggesting that VX-853 are representatives of a new class of bacterial efflux inhibitors with the potential for use in combination therapy.