Gefitinib New
Data Sheet
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| CAS No. | 184475-35-2 | Cat. No. | BCP01365 |
| Name | Gefitinib | ||
| Synonyms | Iressa;ZD-1839;ZD 1839;ZD1839; | ||
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4 | ||
| Chemical Name | |||
| Formula | C22H24ClFN4O3 | M. Wt | 446.9 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy and cell apoptosis, which can be used for cancer related research, such as Lung cancer and breast cancer. | ||
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