EFT-508
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1849590-01-7 | Cat. No. | BCP18993 |
| Name | EFT-508 | ||
| Synonyms | EFT 508;EFT508;Tomivosertib; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H20N6O2 | M. Wt | 340.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | In vitro: eFT508 has a half-maximal inhibitory concentration (IC50) of 1-2 nM against both MNK isoforms in enzyme assays and inhibits the kinase through a reversible, ATP-competitive mechanism of action. eFT508 showed anti-proliferative activity against multiple DLBCL cell lines. In vivo: eFT508 is tested in vivo in 7 subcutaneous human lymphoma xenograft models. Significant anti-tumor activity is observed in the TMD8 and HBL-1 ABC-DLBCL models, both of which harbor activating MyD88 mutations. | ||
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