PD0166285
Data Sheet
For research use only. Not for human use.
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| CAS No. | 185039-89-8 | Cat. No. | BCP20228 |
| Name | PD0166285 | ||
| Synonyms | PD-0166285;PD 0166285; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C26H27Cl2N5O2 | M. Wt | 512.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PD0166285 is identified to inhibit Wee1 activity at nanomolar concentrations. The inhibitor abrogates G2/M checkpoint inducing early cell division. At the cellular level, 0.5 μM PD0166285 dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines tested. This G2 checkpoint abrogation by PD0166285 is demonstrated to kill cancer cells. PD0166285 does not inhibit Cdc2/cyclin B but inhibits Chk1 kinase at a much higher concentration (3433 nM). the treatment of cells with the inhibitor is related to microtubule stabilization and decrease in cyclin D transcription. Thus, PD0166285 may be a potentially useful anti-cancer therapy. PD0166285 at 0.5 μM concentration can inhibit Cdc2Y15 /T14 phosphorylation in all cell lines tested, regardless of their p53 status and pharmacological targeting of WEE1 by PD0166285 sensitizes U251-FM GBM tumors to IR in vivo. | ||
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