ROC-325 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1859141-26-6 | Cat. No. | BCP20110 |
| Name | ROC-325 | ||
| Synonyms | ROC 325;ROC325; | ||
| SMILES | CC1=C2C(=C(C=C1)NCCN(C)CCNC3=C4C=CC(=CC4=NC=C3)Cl)C(=O)C5=CC=CC=C5S2 | ||
| Chemical Name | |||
| Formula | C28H27ClN4OS | M. Wt | 503.06 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ROC-325 is an autophagy inhibitor. ROC-325 exhibited superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in 12 different cancer cell lines with diverse genetic backgrounds. ROC-325 antagonized RCC growth and survival in an ATG5/7-dependent manner, induced apoptosis, and exhibited favorable selectivity. | ||
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