(+/-)-Roscovitine
Data Sheet
For research use only. Not for human use.
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| CAS No. | 186692-44-4 | Cat. No. | BCP19053 |
| Name | (+/-)-Roscovitine | ||
| Synonyms | R-roscovitine;CYC202; CYC202; CYC 202;Seliciclib; | ||
| SMILES | CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C | ||
| Chemical Name | |||
| Formula | C19H26N6O | M. Wt | 354.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Seliciclib, also known as roscovitine and CYC202, is a n orally bioavailable, small-molecule cyclin-dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2/E, CDK2/A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, inhibiting RNA polymerase II-dependent transcription, which may result in the down-regulation of antiapoptotic proteins such as induced myeloid leukemia cell differentiation protein Mcl-1. | ||
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