Eptifibatide New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 188627-80-7 | Cat. No. | BCP02070 |
| Name | Eptifibatide | ||
| Synonyms | 148031-34-9;Eptifibatide acetate; Integrilin; Integrelin; | ||
| SMILES | C1CC2C(=O)NC(CSSCCC(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N2C1)CC3=CNC4=CC=CC=C43)CC(=O)O)CCCCN=C(N)N)C(=O)N | ||
| Chemical Name | |||
| Formula | C35H49N11O9S2 | M. Wt | 831.96 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Eptifibatide is a potent glycoprotein IIb/IIIa antagonist (GPIIb/IIIa; Kd = 120 nM) that inhibits platelet aggregation. Eptifibatide prevents binding of the adhesion proteins fibrinogen and von Willebrand factor to GPIIb/IIIa on the surface of activated platelets to prevent aggregation and thrombus formation. It inhibits ADP-induced citrated blood aggregation (IC50 = 0.11-0.22 μg/ml) in vitro and in vivo (IC50 = 52 μg/ml in porcine plasma). Formulations containing eptifibatide have been used to reduce risk of thrombolysis in myocardial infarction in patients undergoing percutaneous coronary intervention. | ||
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