Oritavancin diphosphate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 192564-14-0 | Cat. No. | BCP24660 |
| Name | Oritavancin diphosphate | ||
| Synonyms | LY333328 diphosphate; LY-333328 diphosphate; LY 333328 diphosphate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C86H103Cl3N10O34P2 | M. Wt | 1989.1 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Oritavancin diphosphate is a novel semisynthetic glycopeptide antibiotic being developed for the treatment of serious Gram-positive bacterial infections.Oritavancin, also known as LY333328, is a novel semisynthetic glycopeptide antibiotics. On August 6, 2014, the FDA approved oritavancin for treatment of skin infections. Oritavancin possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible Gram-positive bacteria, including Staphylococcus aureus, MRSA, enterococci, and streptococci. Oritavancin was more active than either metronidazole or vancomycin against strains of Clostridium difficile tested. Oritavancin has potential use as a therapy for exposure to Bacillus anthracis, the Gram-positive bacterium that causes anthrax, having demonstrated efficacy in a mouse model both before and after exposure to the bacterium. The 4'-chlorobiphenylmethyl group disrupts the cell membrane of Gram-positive bacteria. It also acts by inhibition of transglycosylation and inhibition of transpeptidation. | ||
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