Calcifediol

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01929CAS No. ：19356-17-3Purity：98%

Get Quotation Now

Tel: 0086-17754423994 or orders@biochempartner.com

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

* Required Fields.

Please complete the form below and we will contact you shortly.

* Required Fields.

Please complete the form below and we will contact you shortly.

CAS No.	19356-17-3	Cat. No.	BCP01929
Name	Calcifediol
Synonyms	25-hydroxy Cholecalciferol;25-OH Vitamin D3; Calcidiol;Didrogyl;Hidroferol;25-hydroxy Vitamin D3;RO 8-8892;
SMILES
Chemical Name
Formula	C27H44O2	M. Wt	400.64
Purity	98%	Storage	Store at 4-8°C
Description	Calcifediol is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It is produced in the liver and is the best indicator of the body’s vitamin D stores. It is effective in the treatment of rickets and osteomalacia both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. According to MedlinePlus the normal range of calcidiol is 30.0 to 74.0 ng/mL. Calcifediol suppresses PTH secretion and mRNA (ED50=2 nM), but is several hundred times less potent than 1,25(OH)2D3. The lower potency of calcifediol correlated with its lower VDR affinity. bPTCs converted 25(OH)D3 to 1-hydroxylated metabolites, but the rate of conversion is low. In the pooled analysis, higher circulating calcifediol concentrations were statistically significantly associated with decreased colorectal adenoma risk (highest vs. lowest quartile odds ratio= 0.59, 95% confidence interval: 0.41, 0.84).