Sarizotan HCl New
Data Sheet
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| CAS No. | 195068-07-6 | Cat. No. | BCP18868 |
| Name | Sarizotan HCl | ||
| Synonyms | Sarizotan hydrochloride;EMD-128130; EMD128130; EMD 128130; EMD-77697; EMD-77697; EMD-77697; | ||
| SMILES | C1CC2=CC=CC=C2OC1CNCC3=CN=CC(=C3)C4=CC=C(C=C4)F.Cl | ||
| Chemical Name | |||
| Formula | C22H22ClFN2O | M. Wt | 384.87 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Sarizotan, also known as EMD-128130, is a Dopamine D2 receptor partial agonist and Serotonin 1A receptor agonist. Sarizotan exhibits affinity at serotonin and dopamine receptors. Sarizotan effectively suppresses levodopa-induced dyskinesia in primate and rodent models of Parkinson's disease, and tardive dyskinesia in a rodent model. Sarizotan is a full agonist at D3 and D4.4 receptors (EC50=5.6 and 5.4 nM, respectively) but a partial agonist at D2S, D2L and D4.2 receptors (EC50=29, 23 and 4.5 nM, respectively). Sarizotan is an antagonist at D2S and D2L receptors (IC50=52 and 121 nM, respectively). Sarizotan is a full agonist at D2L, D3, D4.2 and D4.4 receptors (EC50=0.51, 0.47, 0.48 and 0.23 nM, respectively) but a partial agonist at D2S receptors (EC50=0.6 nM). | ||
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