MAK-683
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1951408-58-4 | Cat. No. | BCP29116 |
| Name | MAK-683 | ||
| Synonyms | EED inhibitor-1;CPD 1111; MAK 683; MAK683;CPD1111;CPD-1111; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C20H17FN6O | M. Wt | 376.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MAK-683 is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3-binding pocket and prevents the interaction of EED with the histone methyltransferase enhancer zeste homolog 2 (EZH2). | ||
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