R-Acalabrutinib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1952316-43-6 | Cat. No. | BCP20163 |
| Name | R-Acalabrutinib | ||
| Synonyms | ACP-196; ACP196; ACP 196; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C26H23N7O2 | M. Wt | 465.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Acalabrutinib is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival. | ||
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