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Wortmannin Chemical Structure

Wortmannin

Data Sheet For research use only. Not for human use.
Cat. No. :BCP07861CAS No. :19545-26-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 19545-26-7 Cat. No. BCP07861
Name Wortmannin
Synonyms SL2052; SL-2052; SL 2052;KY-12420;KY 12420;KY12420;
SMILES
Chemical Name
Formula C23H24O8 M. Wt 428.43
Purity 98% Storage Store at 4-8°C
Description Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces (Penicillium) wortmannii, is a specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K.
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