10-Hydroxycamptothecin
Data Sheet
For research use only. Not for human use.
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Publications Citing of Biochempartner's 10-Hydroxycamptothecin
| CAS No. | 19685-09-7 | Cat. No. | BCP01385 |
| Related Products | 64439-81-2（10-Hydroxycamptothecin acetate） | ||
| Name | 10-Hydroxycamptothecin | ||
| Synonyms | (S)-10-Hydroxycamptothecin; 10-HCPT; | ||
| SMILES | O=C1N2C(C3=NC(C=CC(O)=C4)=C4C=C3C2)=CC([C@@]5(O)CC)=C1COC5=O | ||
| Chemical Name | |||
| Formula | C20H16N2O5 | M. Wt | 364.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | 10-Hydroxycamptothecin inhibits the growth of BT-20 and MDA-231 cell with IC50 of 34.3 nM and 7.27 nM, respectively, more potently than camptothecin (CPT) with IC50 of >500 nM. 10-Hydroxycamptothecin potently induces human topoisomerase I-mediated cleavable complex formation of pBR322 plasmid DNA with EC50 of 0.35 μM, displaying >50-fold potency than CPT with EC50 of 18.85 μM. 10-Hydroxycamptothecin treatment induces dose-dependent growth inhibition of human microvascular endothelial cells (HMEC | ||
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