Amiodarone hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 19774-82-4 | Cat. No. | BCP13645 |
| Name | Amiodarone hydrochloride | ||
| Synonyms | Nexterone; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C25H29I2NO3.ClH | M. Wt | 681.77 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: It was found that 10 uM amiodarone induces accumulation of ethidium bromide (5 ug/ml) in Saccharomyces cerevisiae cells. At the same time, in yeast cells with inactivated MDR genes, accumulation of ethidium bromide was 6-fold higher even without amiodarone. Addition of non-lethal concentrations of amiodarone to MDR-deficient cells caused an increase of intracellular ethidium bromide to the level, which was even lower than the level in amiodarone-treated wild-type cells . Cells treated with amiodarone were seen to have detached from the dish, with cell rounding, cytoplasmic blebbing and irregularity in shape. An increase in the sub-G1 phase fraction, from 15.43 to 21.34% and 79.83% and a reduction in the G1 phase fraction, from 48.83 to 41.63% and 11.52%, were observed in cells treated with amiodarone at concentrations of 0.1 and 1 mM, respectively. in vivo: Chronic treatment with oral amiodarone for 4 weeks reduced i.p. when myocytes were dialyzed with patch-pipettes containi | ||
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