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ML364 Chemical Structure

ML364

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP20769CAS No. ：1991986-30-1Purity：
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  • Chemical Properties&Biological Activity
CAS No. 1991986-30-1 Cat. No. BCP20769
Name ML364
Synonyms ML-364;ML 364;
SMILES
Chemical Name
Formula C24H18F3N3O3S2 M. Wt 517.54
Purity Storage Store at 4-8°C
Description ML364 is a small molecule inhibitor of the deubiquitinase USP2 with potential anticancer activity. ML364 has an IC50 of 1.1 μm in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate. Direct binding of ML364 to USP2 was demonstrated using microscale thermophoresis. ML364 induced an increase in cellular cyclin D1 degradation and caused cell cycle arrest as shown in Western blottings and flow cytometry assays utilizing both Mino and HCT116 cancer cell lines.
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H-NMR HPLC
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