Amiloride hydrochloride
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 2016-88-8 | Cat. No. | BCP15584 |
| Name | Amiloride hydrochloride | ||
| Synonyms | MK-870 hydrochloride; Midamor hydrochloride; Guanamprazine hydrochloride; Amipramidin hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C6H8ClN7O.HCl | M. Wt | 266.09 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Amiloride is a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. Amiloride works by directly blocking the epithelial sodium channel (ENaC) thereby inhibiting sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts in the kidneys. This promotes the loss of sodium and water from the body, but without depleting potassium . Amiloride, the first ENaC blocker to be applied to δβγ channels, has an IC50 of 2.6 μM. The Ki of amiloride for δβγ ENaC is 26-fold that of αβγ channels (0.1 μM for αβγ ENaC). The Ki of amiloride for δαβγ channels was 920 and 13.7 μM at ?120 and +80 mV, respectively, which significantly dif | ||
Recommend Products
More >
-
-
Atomoxetine
Cat. No.：BCP49119
No.：83015-26-3
Product Details -
SLC13A5-IN-1
Cat. No.：BCP48912
No.：2227548-95-8
Product Details -
-
-
CRMP2-Ubc9-NaV1.7 inhibitor 194
Cat. No.：BCP44631
No.：2241651-99-8
Product Details -
-
-
-
Licarbazepine
Cat. No.：BCP35919
No.：29331-92-8
Product Details -
Oxcarbazepine
Cat. No.：BCP33398
No.：28721-07-5
Product Details -
Lidocaine N-ethyl bromide
Cat. No.：BCP33056
No.：21306-56-9
Product Details -
QX-314 chloride
Cat. No.：BCP33036
No.：5369-03-9
Product Details -
Eleclazine Hydrochloride
Cat. No.：BCP32600
No.：1448754-43-5
Product Details -
Eleclazine
Cat. No.：BCP32599
No.：1443211-72-0
Product Details -
BI 01383298
Cat. No.：BCP32582
No.：2227549-00-8
Product Details -
Sipatrigine
Cat. No.：BCP31183
No.：130800-90-7
Product Details -
PF-06869206
Cat. No.：BCP31135
No.：2227425-05-8
Product Details -
-
Tags:Amiloride hydrochloride supplier,Amiloride hydrochloride purchase,Amiloride hydrochloride manufacturer,Amiloride hydrochloride distributor,Amiloride hydrochloride cost,Amiloride hydrochloride buy,Amiloride hydrochloride for sale