AMI-1

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP15937CAS No. ：20324-87-2Purity：98%

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CAS No.	20324-87-2	Cat. No.	BCP15937
Name	AMI-1
Synonyms	AMI 1;AMI1;
SMILES
Chemical Name
Formula	C21H14N2Na2O9S2	M. Wt	548.45
Purity	98%	Storage	Store at 4-8°C
Description	n vitro: AMI-1 suppresses the transcriptional coactivator activity of PRMT1 and PRMT4 and it inhibits HIV-1 RT polymerase (IC50 = 5.0μM). PRMT1 methylates histone H4, and is essential for other subsequent histone modifications.[1] AMI-1 is the most active nonpeptidic inhibitor reported to be selective against PRMT1. AMI-1 is a selective PRMT inhibitor with a bisanionic structure that is related to compounds known to generate pleiotropic interactions with many proteins, should be further optimized before exploring additional binding pockets. in vivo: AMI-1 is administered intranasally to chronic AIPI rats to determine PRMT effects on asthmatic parameters. AMI-1 inhibited the expression of COX2 in TGF-β-stimulated cells. AMI-1 administered to AIPI rats reduced COX2 production and humoral immune response, and it abrogated mucus secretion and collagen generation.