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GDC-0994 hydrochloride Chemical Structure

GDC-0994 hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20235CAS No. :2070009-58-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2070009-58-2 Cat. No. BCP20235
Name GDC-0994 hydrochloride
Synonyms GDC 0994 hydrochloride;GDC0994 hydrochlorideRavoxertinib hydrochloride;
SMILES
Chemical Name
Formula C21H19Cl2FN6O2 M. Wt 477.32
Purity 98% Storage Store at 4-8°C
Description GDC-0994 also inhibits p90RSK with IC50 of 12 nM[1]. GDC-0994 is highly selective for ERK1 and ERK2, with biochemical potency of 1.1 nM and 0.3 nM, respectively. In CD-1 mice, a 10 mg/kg oral dose of GDC-0994 is sufficient to achieve the desired target coverage for at least 8 h[1]. Daily, oral dosing of GDC-0994 results in significant single-agent activity in multiple in vivo cancer models, including KRAS-mutant and BRAF-mutant human xenograft tumors in mice.
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