R-5-Hydroxymethyl Tolterodine
Data Sheet
For research use only. Not for human use.
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| CAS No. | 207679-81-0 | Cat. No. | BCP02922 |
| Name | R-5-Hydroxymethyl Tolterodine | ||
| Synonyms | PNU 200577;Desfesoterodine;PNU-200577;5-HMT;5-HM; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H31NO2 | M. Wt | 341.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | 5-hydroxymethyl tolterodine is a major pharmacologically active metabolite of tolterodine. 5-hydroxymethyl tolterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. 5-hydroxymethyl tolterodine antagotizes muscarinic receptors with a pA2 of 9.1. 5-hydroxymethyl tolterodine causes a concentration-dependent inhibition of (-)3 H-QNB binding in homogenates of guinea-pig urinary bladder, parotid gland, heart and cerebral cortex.5-hydroxymethyl tolterodine has a similar pharmacological profile with tolterodine. Intravenous infusion of 5-hydroxymethyl tolterodine produces a dose-dependent inhibition of the intravesical volume-induced urinary bladder contraction measured as the micturition pressure. | ||
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