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EED226 Chemical Structure

EED226

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP19849CAS No. ：2083627-02-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 2083627-02-3 Cat. No. BCP19849
Name EED226
Synonyms EED-226; EED 226;
SMILES
Chemical Name
Formula C17H15N5O3S M. Wt 369.40
Purity 98% Storage Store at 4-8°C
Description EED226 is a potent, selective, and orally bioavailable EED inhibitor. induces robust and sustained tumor regression in EZH2MUT preclinical DLBCL model. EED226 induces a conformational change upon binding EED, leading to loss of PRC2 activity. EED226 shows similar activity to SAM-competitive inhibitors in blocking H3K27 methylation of PRC2 target genes and inducing regression of human lymphoma xenograft tumors. Interestingly, EED226 also effectively inhibits PRC2 containing a mutant EZH2 protein resistant to SAM-competitive inhibitors. EED226 inhibits PRC2 activity via an allosteric mechanism and offers an opportunity for treatment of PRC2-dependent cancers. demonstrated very impressive antitumor activities in mouse xenograft model.
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