AZD4205 New
Data Sheet
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| CAS No. | 2091134-35-7 | Cat. No. | BCP46221 |
| Name | AZD4205 | ||
| Synonyms | JAK1-IN-4; AZD-4205; AZD 4205; | ||
| SMILES | CC1CN(CCN1C)C(C)C(=O)NC2=CC=CC3=C2NC=C3C4=NC(=NC=C4F)NC5=CN(N=C5OC)C | ||
| Chemical Name | |||
| Formula | C26H32FN9O2 | M. Wt | 521.6 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AZD4205 is a potent, selective JAK1 inhibitor IC50 of 73 nM and Ki of 2.8 nM, shows high selectivity against JAK2 and JAK3 with IC50 of 13,233 nM and >30,000 nM respectively; shows potent inhibition of p-STAT3 in a cell based assay of JAK1 activity with an IC50 of 128 nM and excellent selectivity across the kinome; reduces residual disease and prolongs the benefit of Osimertinib in lung cancer patients with EGFR activating mutations both in vitro and in vivo. | ||
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