SB271046 HCl
Data Sheet
For research use only. Not for human use.
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| CAS No. | 209481-20-9 | Cat. No. | BCP03713 |
| Name | SB271046 HCl | ||
| Synonyms | SB-271046;SB 271046;SB 271046 Hydrochloride; SB-271046 HCl; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C20H22CIN3O3S2.HCl | M. Wt | 488.45 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SB271046 Hcl is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.SB-271046 is one of the first selective 5-HT6 receptor antagonists to be discovered. SB-271046 was found to be potent and selective in vitro and had good oral bioavailability in vivo, but had poor penetration across the blood–brain barrier. SB-271046 was found to increase levels of the excitatory amino acid neurotransmitters glutamate and aspartate, as well as dopamine and noradrenaline in the frontal cortex and hippocampus of rats, and 5-HT6 antagonists have been shown to produce nootropic effects in a variety of animal studies. Suggested applications of these drugs include treatment of schizophrenia and other psychiatric disorders. | ||
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