VH-298
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2097381-85-4 | Cat. No. | BCP20719 |
| Name | VH-298 | ||
| Synonyms | VH 298; VH298; | ||
| SMILES | O=C([C@]1N(C([C@](C(C)(C)C)NC(C2(CC2)C#N)=O)=O)C[C@](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3 | ||
| Chemical Name | |||
| Formula | C27H33N5O4S | M. Wt | 523.65 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes. VH298 represents a high-quality chemical probe of the HIF signalling cascade and an attractive starting point to the development of potential new therapeutics targeting hypoxia signalling. | ||
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