Sobetirome New
Data Sheet
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| CAS No. | 211110-63-3 | Cat. No. | BCP23779 |
| Name | Sobetirome | ||
| Synonyms | GC-1; GC1; GC 1; QRX-431; QRX 431; QRX431; | ||
| SMILES | O=C(O)COC1=CC(C)=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=C1 | ||
| Chemical Name | |||
| Formula | C20H24O4 | M. Wt | 328.4 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Sobetirome, also known as GC-1 and QRX-431, is a hyroid hormone beta-receptor agonist. Sobetirome inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast-like cells. Sobetirome selectively binds to and activates TRbeta over TRalpha and this receptor selectivity led to the hypothesis that sobetirome would lower cholesterol through activation of liver TRbeta without stimulating cardiac function through TRalpha activation in the heart. The tissue selective thyromimetic properties of sobetirome have been demonstrated in numerous animal models, which led to its clinical development as a novel cholesterol-lowering agent. | ||
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