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RITA Chemical Structure

RITA

Data Sheet For research use only. Not for human use.
Cat. No. :BCP06744CAS No. :213261-59-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 213261-59-7 Cat. No. BCP06744
Name RITA
Synonyms p53 Activator III, RITA; NSC 652287; NSC-652287; NSC652287; Sos Bismethanol;
SMILES OCC1=CC=C(C2=CC=C(C3=CC=C(CO)S3)O2)S1
Chemical Name
Formula C14H12O3S2 M. Wt 292.37
Purity 98% Storage Store at 4-8°C
Description RITA (NSC 652287) is a DNA damaging agent with IC50 of 2 nM and 20 nM in A498 and TK-10 cells.Anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo.
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