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Lisaftoclax Chemical Structure

Lisaftoclax

Data Sheet For research use only. Not for human use.
Cat. No. :BCP47569CAS No. :2180923-05-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2180923-05-9 Cat. No. BCP47569
Name Lisaftoclax
Synonyms APG-2575;APG2575;APG 2575;Bcl-2/Bcl-xl inhibitor 1;
SMILES C1CC2(C1)CCC(=C(C2)C3=CC=C(C=C3)Cl)CN4CCN(CC4)C5=CC(=C(C=C5)C(=O)NS(=O)(=O)C6=CC(=C(C=C6)NCC7COCCO7)[N+](=O)[O-])OC8=CN=C9C(=C8)C=CN9
Chemical Name
Formula C45H48ClN7O8S M. Wt 882.42
Purity 98% Storage Store at 4-8°C
Description Lisaftoclax is an orally bioavailable and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, lisaftoclax targets, binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival.
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