ANA-12

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16021CAS No. ：219766-25-3Purity：98%

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CAS No.	219766-25-3	Cat. No.	BCP16021
Name	ANA-12
Synonyms	ANA12;ANA 12;
SMILES
Chemical Name
Formula	C22H21N3O3S	M. Wt	407.49
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: ANA-12 prevented activation of the receptor by BDNF with a high potency. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Saturation binding studies with TrkBECD-Fc showed that ANA-12 binds TrkBECD-Fc with a Kd of 12 μM [1]. The selective TrkB (tropomyosin-receptor-kinase) antagonist ANA-12 reduced OIH when given one or seven days after cessation of morphine. in vivo: Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans [1]. Administration of a BDNF receptor antagonist (the TrkB receptor antagonist ANA-12) reversed the diminished cocaine self-administration in male cocaine-sired rats.