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Ki8751 Chemical Structure

Ki8751

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02842CAS No. ：228559-41-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 228559-41-9 Cat. No. BCP02842
Name Ki8751
Synonyms Ki 8751;Ki-8751;
SMILES
Chemical Name
Formula C24H18F3N3O4 M. Wt 469.41
Purity 98% Storage Store at 4-8°C
Description Ki8751 potently and selectively inhibits VEGFR2 with IC50 of 0.9 nM. Ki8751 also inhibits PDGFRα, c-Kit, and FGFR-2, with much higher IC50 values (40 nM–170 nM). Except for these several kinases, Ki8751 doesn't disturb other kinases, including HGFR, EGFR, and InsulinR, even at 10 μM. In human umbilical vein endothelial cells (HUVECs), Ki8751 (1 nM–100 nM) effectively decreases VEGF-stimulated cell proliferation and vasculature permeability. In metastatic colorectal cancer (CRC) cells MIP, RKO, SW620, and SW480, but not in HCT116, Ki8751 (10 nM) increases cellular senescence.
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