EBE-A22

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP20742CAS No. ：229476-53-3Purity：98%

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CAS No.	229476-53-3	Cat. No.	BCP20742
Name	EBE-A22
Synonyms	EBE-A 22;EBE A22; EBEA22;
SMILES	BrC1=CC(N(C)C2=NC=NC3=CC(OC)=C(OC)C=C23)=CC=C1
Chemical Name
Formula	C17H16BrN3O2	M. Wt	374.23
Purity	98%	Storage	Store at 4-8°C
Description	EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive. The brominated anilinoquinazoline derivative PD153035 exhibits a very high affinity and selectivity for the epidermal growth factor receptor tyrosine kinase (EGF-R TK) and shows a remarkable cytotoxicity against several types of tumor cell lines. In contrast, its N-methyl derivative, designated EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. The present study was performed to explore the possibility that PD153035 and its N-methyl analogue might interact with double-stranded DNA, which is a primary target for many conventional antitumor agents. We studied the strength and mode of binding to DNA of PD153035 and EBE-A22 by means of absorption, fluorescence, and circular and linear dichroism as well as by a relaxation assay using human DNA topoisomerases. The results of various optical and gel electrophoresis techniques converge to show that both drugs bind