Exherin New
Data Sheet
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| CAS No. | 229971-81-7 | Cat. No. | BCP06830 |
| Name | Exherin | ||
| Synonyms | ADH 1;ADH-1;ADH1; | ||
| SMILES | CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CN=CN2)NC(=O)C)C(=O)N)C(C)C | ||
| Chemical Name | |||
| Formula | C22H34N8O6S2 | M. Wt | 570.68 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels. | ||
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