Dulcitol diepoxide New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 23261-20-3 | Cat. No. | BCP19033 |
| Name | Dulcitol diepoxide | ||
| Synonyms | Dianhydrogalactitol;VAL-083;VAL083;VAL 083; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C6H10O4 | M. Wt | 146.14 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | VAL-083 inhibited U251 and SF188 cell growth in monolayer and as neurospheres better than TMZ and caused apoptosis after 72 hr. In the colony formation assay, VAL-083 (5 uM) suppressed SF188 growth by about 95%. T98G cells are classically TMZ-resistant and express MGMT, but VAL-083 inhibited their growth in monolayer after 72 hr in a dose-dependent manner (IC50, 5 uM). VAL-083 also inhibited the growth of CSCs (BT74, GBM4, and GBM8) by 80-100% in neurosphere self-renewal assays. Conversely, there was minimal effect on normal human neural stem cells. | ||
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