Isavuconazole
Data Sheet
For research use only. Not for human use.
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| CAS No. | 241479-67-4 | Cat. No. | BCP07587 |
| Name | Isavuconazole | ||
| Synonyms | BAL-4815;BAL4815;BAL 4815;RO-0094815;RO0094815;RO 0094815; | ||
| SMILES | FC1=CC=C(F)C=C1[C@](CN2C=NC=N2)(O)[C@@H](C)C3=NC(C4=CC=C(C#N)C=C4)=CS3 | ||
| Chemical Name | |||
| Formula | C22H17F2N5OS | M. Wt | 437.47 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Isavuconazole, also knownc as BAL4815 and RO 0094815, is a triazole antifungal drug. Its prodrug, isavuconazonium sulfate (BAL8557), was granted approval by the U.S. Food and Drug Administration (FDA) on March 6, 2015 for the treatment of invasive candidiasis. Isavuconazole works by inhibiting lanosterol 14 alpha-demethylase, the enzyme responsible for converting lanosterol to ergosterol by demethylation. The resulting depletion of ergosterol and build up of lanosterol compromise the structure of the fungal cell membrane. Mammalian cells are resistant to demethylation inhibition by azoles, making the drug effects specific to fungi. | ||
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