Pyr6
Data Sheet
For research use only. Not for human use.
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| CAS No. | 245747-08-4 | Cat. No. | BCP16455 |
| Name | Pyr6 | ||
| Synonyms | Pyr-6;Pyr 6; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H9F7N4O | M. Wt | 418.27 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pyr6 is a selective SOCE inhibitor (Yonetoku et al., 2008; Sweeney et al., 2009), Pyr6 displayed 37-fold (1.58 OM) higher potency for RBL SOCE than for TRPC3 ROCE, with an IC50 comparable to that of Pyr2 and Pyr3. Pyr6 at 3 uM diminished TRPC3 currents to only 52%. Consistent with inhibition of Orai channel activity Pyr2, Pyr3 or Pyr6 substantially inhibited typical Orai downstream signalling events in RBL mast cells (NFAT activation and degranulation) activated by passive store depletion. | ||
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