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UK-371804 Chemical Structure

UK-371804

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP19928CAS No. ：256477-09-5Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 256477-09-5 Cat. No. BCP19928
Name UK-371804
Synonyms UK 371804;UK371804;Urokinase inhibitor 1; UK-371,804; UK 371,804; UK371,804;
SMILES CC(C(O)=O)(C)NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2NC(N)=N)=O
Chemical Name
Formula C14H16ClN5O4S M. Wt 385.82
Purity 98% Storage Store at 4-8°C
Description UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). In vitro, UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. UK-371804 was selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulcers.
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