ESI-09
Data Sheet
For research use only. Not for human use.
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| CAS No. | 263707-16-0 | Cat. No. | BCP10854 |
| Name | ESI-09 | ||
| Synonyms | ESI09;ESI 09; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H15ClN4O2 | M. Wt | 330.77 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ESI-09 inhibited cAMP-mediated EPAC2 GEF activity with an apparent IC50 of 1.4± 0.1 uM. Similarly, ESI-09 was also effective in suppressing cAMP-mediated EPAC1 GEF activity with an apparent IC50 of 3.2± 0.4 uM. ESI-09 is capable of blocking EPAC-mediated Akt activation, the phosphorylation status of T308 and S473 of Akt in the pancreatic cancer cell line AsPC-1, which overexpresses EPAC1, was followed using antiphospho-Akt antibodies. when the pancreatic cancer cell lines AsPC-1 and PANC-1 were pretreated with ESI-09, a significant decrease in cell migration was observed using both Transwell migration/invasion and wound healing assays. | ||
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