Glibornuride New
Data Sheet
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| CAS No. | 26944-48-9 | Cat. No. | BCP13008 |
| Name | Glibornuride | ||
| Synonyms | |||
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC2C3CCC(C2O)(C3(C)C)C | ||
| Chemical Name | |||
| Formula | C18H26N2O4S | M. Wt | 366.47 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Glibornuride is an orally bioavailable sulfonamide urea derivative with antihyperglycemic activity. Upon administration, glibornuride binds to and blocks the sulfonylurea receptor type 1 (SUR1) subunit of the ATP-sensitive inwardly-rectifying potassium (K(ATP)) channels on the membranes of pancreatic beta cells. This prevents the inward flow of positively charged potassium (K+) ions into the cell, and induces a calcium ion (Ca2+) influx through voltage-sensitive calcium channels, which triggers exocytosis of insulin-containing granules. Insulin stimulates glycogen synthesis and inhibits gluconeogenesis, which together lower blood glucose levels. | ||
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