Tirapazamine
Data Sheet
For research use only. Not for human use.
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| CAS No. | 27314-97-2 | Cat. No. | BCP03663 |
| Name | Tirapazamine | ||
| Synonyms | WIN-59075; WIN 59075; SR 259075;SR-259075;SR259075;SR4233;SR 4233;SR-4233;Tirazone;Win59075;NSC130181;NSC-130181;NSC 130181; | ||
| SMILES | C1=CC=C2C(=C1)N(C(=N)N=[N+]2[O-])O | ||
| Chemical Name | |||
| Formula | C7H6N4O2 | M. Wt | 178.15 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Tirapazamine is a benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. Check for active clinical trials or closed clinical trials using this agent. | ||
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