Nigericin

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP13661CAS No. ：28380-24-7Purity：98%

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CAS No.	28380-24-7	Cat. No.	BCP13661
Name	Nigericin
Synonyms	Azalomycin M; Polyetherin A; Helixin C; Antibiotic K178; Antibiotic X464; 28643-80-3（Nigericin sodium salt）;
SMILES	CC1CCC(OC1C(C)C(=O)O)CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC
Chemical Name
Formula	C40H68O11	M. Wt	724.97
Purity	98%	Storage	Store at 4-8°C
Description	Nigericin is an antibiotic derived from Streptomyces hygroscopicus. Its isolation was described in the 1950s, and in 1968 the structure could be elucidated by X-ray crystallography. The structure and properties of nigericin are similar to the antibiotic monensin. Commercially it is obtained as a byproduct, or contaminant, at the fermentation of Geldanamycin. It is also called Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464. Nigericin acts as an H+, K+, Pb2+ ionophore. Most commonly it is an antiporter of H+ and K+. In the past nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions in Eukaryotic cells. Nigericin exhibits anticancer and anti-HIV activity.