CCG-1423

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP13571CAS No. ：285986-88-1Purity：98%

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CAS No.	285986-88-1	Cat. No.	BCP13571
Name	CCG-1423
Synonyms	CCG1423;CCG 1423;
SMILES
Chemical Name
Formula	C18H13ClF6N2O3	M. Wt	454.75
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: CCG-1423 selectively inhibited spontaneous PC-3 prostate cancer cell invasion through a Matrigel matrix, but not the Gαi-dependent LPA-stimulated SKOV-3 ovarian cancer cell invasion, in vitro. At 100 μM, nearly complete inhibition of invasion was achieved with a lesser degree of toxicity than that induced by CCG-1423 at 10 μM [1]. SRF binds to this site in vivo and the SRF inhibitor CCG-1423 completely blocks STARS proximal reporter activity in H9c2 cells. pharmacological MKL-inhibition with CCG-1423 significantly inhibited CCN1 promoter activity as well as mRNA and protein expression[4]. in vivo: Pharmacological SRF inhibition by CCG-1423 reduced nuclear MKL1 and improved glucose uptake and tolerance in insulin-resistant mice in vivo.