KRN633

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP23436CAS No. ：286370-15-8Purity：98%

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CAS No.	286370-15-8	Cat. No.	BCP23436
Name	KRN633
Synonyms	KRN-633;KRN 633;
SMILES
Chemical Name
Formula	C20H21ClN4O4	M. Wt	416.86
Purity	98%	Storage	Store at 4-8°C
Description	KRN633 is a potent and selective VEGFR inhibitor. which inhibits tyrosine phosphorylation of VEGFR-2 (IC50 = 1.16 nmol/L) in human umbilical vein endothelial cells. Selectivity profiling with recombinant tyrosine kinases showed that KRN633 is highly selective for VEGFR-1, -2, and -3. KRN633 inhibits tumor growth in several in vivo tumor xenograft models with diverse tissue origins, including lung, colon, and prostate, in athymic mice and rats. KRN633 also causes the regression of some well-established tumors and those that had regrown after the cessation of treatment. KRN633 was well tolerated and had no significant effects on body weight or the general health of the animals. KRN633 might be useful in the treatment of solid tumors and other diseases that depend on pathologic angiogenesis.