Fatostatin A HBr
Data Sheet
For research use only. Not for human use.
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| CAS No. | 298197-04-3 | Cat. No. | BCP20908 |
| Name | Fatostatin A HBr | ||
| Synonyms | Fatostatin A Hydrobromide;Fatostatin A; | ||
| SMILES | CCCC1=NC=CC(C2=NC(C3=CC=C(C)C=C3)=CS2)=C1.[H]Br | ||
| Chemical Name | |||
| Formula | C18H18N2S.HBr | M. Wt | 375.33 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Sterol regulatory element binding proteins (SREBPs) are transcription factors that have pivotal roles in lipogenesis and fat metabolism.The activation of SREBPs requires escort to the Golgi by SREBP cleavage-activating protein (SCAP) followed by proteolytic release of SREBP from the Golgi. Fatostatin is an inhibitor of SREBP activation, preventing SCAP-mediated escort of either SREBP-1 or SREBP-2 to the Golgi (IC50 = 5.6 μM).This blocks constitutive SREBP-mediated gene expression in the human prostate cancer cell line DU145.Fatostatin prevents insulin-induced adipogenesis of 3T3-L1 cells as well as growth induced by insulin-like growth factor 1 in DU145 cells (IC50 = 0.1 μM).Through its actions on SCAP/SREBP-1, it inhibits high glucose-induced upregulation of TGF-β in primary rat mesangial cells.This compound also alters lipid metabolism in vivo, reducing hepatic fat accumulation in ob/ob mice. | ||
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