Polmacoxib New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP15550CAS No. ：301692-76-2Purity：98%

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CAS No.	301692-76-2	Cat. No.	BCP15550
Name	Polmacoxib
Synonyms	CG100649; CG-100649; CG 100649;
SMILES	CC1(C(=O)C(=C(O1)C2=CC=C(C=C2)S(=O)(=O)N)C3=CC(=CC=C3)F)C
Chemical Name
Formula	C18H16FNO4S	M. Wt	361.39
Purity	98%	Storage	Store at 4-8°C
Description	Polmacoxib, also known as CG100649, is a first-in-class NSAID drug candidate that is a dual inhibitor of COX-2 and carbonic anhydrase (CA). CG100649's interaction with CA in red blood cells provides it with a novel 'tissue-specific' transport mechanism that is designed to deliver sustained levels of drug to inflamed tissues, while maintaining low systemic exposure. Its unique dual COX-2 and CA binding properties are designed to provide potentially superior safety to cardiovascular, renal, and gastrointestinal tissues compared to traditional NSAIDs or COX-2 inhibitor drugs. CG100649 inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.